P170 Dauchy, C.; Bautin, N.; Nseir, S.; Reboux, G.; Wintjens, R.; Le Rouzic, O.; Sendid, B.; Viscogliosi, E.; Le Pape, P.; Arendrup, M.C.; Gosset, P.; Fry, S.; Fréalle, E. Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes. Indoor Air 2018, 28, 298-306. doi: 10.1111/ina.12436

P171 Parra-Giraldo, C.M.; Valderrama, S.L.; Cortes-Fraile, G.; Garzón, J.R.; Ariza, B.E.; Morio, F.; Linares-Linares, M.Y.; Ceballos-Garzón, A.; de la Hoz, A.; Hernandez, C.; Alvarez-Moreno, C.; Le Pape P. First report of sporadic cases of Candida auris in Colombia. Int. J. Infect. Dis. 2018, 69, 63-67. doi: 10.1016/j.ijid.2018.01.034.

P172 Morio, F.; Dannaoui, E.; Chouaki, T.; Cateau, E.; Malard, O.; Bonfils, P.; Page, C.; Dufour, X.; Cottrel, C.; Erwan, T.; Lavergne, R.-A.; Le Pape, P. PCR-based detection of A. fumigatus and absence of azole resistance due to TR34/L98H in a french multicenter cohort of 137 patients with fungal rhinosinusitis. Mycoses 2018, 61, 30-34. doi: 10.1111/myc.12702

P173 Dao, V.H.; Ourliac-Garnier, I.; Bazin, M.-A.; Jacquot, C.; Baratte, B.; Ruchaud, S.; Bach, S.; Grovel, O.; Le Pape, P.; Marchand, P. Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: synthesis and evaluation of fluconazole susceptibility restoration. Bioorg. Med. Chem. Lett. 2018, 28, 2250-2255. doi: 10.1016/j.bmcl.2018.05.044

P174 Ropars, J.; Diogo, D.; Marcet-Houben, M.; Perin, A.; Sertour, N.; Mosca, K.; Permal, E.; Laval, G.; Bouchier, C.; Ma, L.; Schwartz, K.; Voelz, K.; May, R.C.; Poulain, J.; Battail, C.; Wincker, P.; Borman, A.M.; Chowdhary, A.; Kim, S.H.; Le Pape, P.; Romeo, O.; Shin, J.H.; Gabaldon, T.; Sherlock, G.; Bougnoux, M.E.; d'Enfert, C. Gene flow contributes to diversification of the major fungal pathogen Candida albicans. Nat. Commun. 2018, 9, 2253. doi:10.1038/s41467-018-04787-4.

P175 Gouin, S.; Lehot, V.; Brissonnet, Y.; Dussouy, C.; Cabanettes, A.; Gillon, E.; Deniaud, D.; Varrot, A.; Le Pape, P. Multivalent fucosides with nanomolar affinity for the Aspergillus fumigatus lectin flea prevent spore adhesion to pneumocytes. Chem. Eur. J. 2018, 24, 19243-19249. doi: 10.1002/chem.201803602

P176 Gaisne, R.; Jeddi, F.; Le Clerc, Q. C.; Morio, F.; Hourmant, M.; Blancho, G.; Giral, M.; Cantarovitch, D.; Dantal, J.; Ville, S. Candida utilis fungaemia following endoscopic intervention on ureteral stent in a kidney transplant recipient: case report and a review of the literature. Mycoses 2018, 61, 594-599. doi: 10.1111/myc.12766.

P177 Winfield, H. J.; Cahill, M. M.; O’Shea, K. D.; Pierce, L. T.; Robert, T.; Ruchaud, S.; Bach, S.; Marchand, P.; McCarthy, F. O. Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg. Med. Chem. 2018, 26, 4209-4224. doi: 10.1016/j.bmc.2018.07.012.

P178 Oyallon, B.; Brachet-Botineau, M.; Logé, C.; Bonnet, P.; Souab, M.; Robert, T.; Ruchaud, S.; Bach, S.; Berthelot, P.; Gouilleux, F.; Viaud-Massuard, M.-C.; Denevault-Sabourin, C. Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. Eur. J. Med. Chem. 2018, 154, 101-109. doi: 10.1016/j.ejmech.2018.04.056

P179 Iradyan, M. A.; Iradyan, N.S.; Hambardzumyn, A. A.; Panosyan, H. A.; Tamazyan, R. A.; Ayvazyan, A. G.; Hovhannisyan, G. S.; Alves de sousa, R.; Sakanyan, V. A. Selective N-, S-alkylation of 4-allyl-3-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4,5-dihydro-1h-1,2,4-triazole-5-thiones with substituted benzylchlorides. synthesis, docking analysis and cytotoxic action. Chem. J. Arm. 2018, 71, 389–406.

P180Iradyan, M. A.; Iradyan, N. S.; Hambardzumyan, A. A.; Minasyan, N. S.; Roussakis, C.; Sakanyan, V. A. Synthesis of furfuryl derivatives of 4-allyl-1-(4-hydroxy-3-nitrobenzyl)-3-[2- (4-alkoxyphenyl)-quinolin-4-yl]-4,5-dihydro-1H-1,2,4-triazole-5-thions and their toxicity in cancer cells. Chem. J. Arm. 2018, 71, 559–570.

P181 Reynoso, J. E.; Salgado-Zamora, H.; Bazin, M.-A.; Campos-Aldrete, M. E.; Marchand, P. Design and synthesis of imidazo[1,2-a]pyridines with carboxamide group substitution and in silico evaluation of their interaction with a LuxR-type quorum sensing receptor. J. Heterocycl. Chem. 2018, 55, 1101-1111. doi: 10.1002/jhet.3140

P182 Dembélé, O.; Montoir, D.; Yvorra, T.; Sérillon, D.; Tonnerre, A.; Duflos, M.; Robert, J.-M.; Bazin, M.-A. Novel approach towards 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound. Tetrahedron Lett. 2018, 59, 3519-3523. doi: 10.1016/j.tetlet.2018.08.013
 

P183 Hamprecht, A.; Morio, F.; Bader, O.; Le Pape, P.; Steinmann, J.; Dannaoui, E. Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern? Mycopathologia 2018 183, 151-160. doi : 10.1007/s11046-017-0162-4

P184 Amoussou, N. G.; Bigot, A.; Roussakis, C.; Robert, J.-M. Haspin: a promising target for the design of inhibitors as potent anticancer drugs. Drug Discov. Today. 2018, 23, 409-415. doi : 10.1016/j.drudis.2017.10.005

P185 Sakanyan, V. Reactive Chemicals and Electrophilic Stress in Cancer: A Minireview. High-Throughput 2018, 7, 12; https://doi.org/10.3390/ht7020012.