P29. Loidreau, Y.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Loaëc, N.; Meijer, L.; Besson, T.; Marchand, P. Exploring kinase inhibition properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine derivatives. Pharmaceuticals 2020, 13, 8; doi: 10.3390/ph13050089.

P28. Aldholmi, M.; Marchand, P.; Ourliac-Garnier, I.; Le Pape, P.; Ganesan, A. A decade of antifungal leads from natural products: 2010-2019. Pharmaceuticals 2019, 12, 182; doi:10.3390/ph12040182.

P27. Mistry, S. N.*; Marchand, P.*; Kellam, B. 27th Annual GP2A Medicinal Chemistry Conference. Pharmaceuticals - Meeting Report. 2019, 12, 179; doi:10.3390/ph12040179.

P26. Nascimento da Cruz, A. C.; Brondani, D .J.; I´talo de Santana, T.; Oliveira da Silva, L.; da Oliveira Borba, E. F.; de Faria, A. R.; Ferreira Cavalcanti de Albuquerque, J.; Piessard, S.; Matos Ximenes, R.; Baratte, B.; Bach, S.; Ruchaud, S.; Bezerra Mendonça Junior, F. J.; Bazin, M.-A.; Montenegro Rabello, M.; Hernandes, M. Z.; Marchand, P.*; Gonçalves da Silva, T*. Biological evaluation of arylsemicarbazone derivatives as potential anticancer agents. Pharmaceuticals 2019, 12, 169; doi:10.3390/ph12040169.

P25. Pereira, P. S.; de Lima, M. D. C. A.; Neto, P. P. M.; Oliveira-Tintino, C. D. D. M.; Tintino, S. R.; Menezes, I. R. D. A.; de Oliveira, J. F.; Marchand, P.; Coutinho, H. D. M.; Rodrigues, M. D. D.; da Silva, T. G. Thiazolidinedione and thiazole derivatives potentiate Norfloxacin activity against NorA efflux pump overexpression in Staphylococcus aureus 1199B strains. Bioorg. Med. Chem. 2019, 27, 3797-3804.

P24. Roque Marques, K. M.; do Desterro, M. R.; de Arruda, S. M.; de Araújo Neto, L. N.; de Lima, M. D. C. A.; de Almeida, S. M. V.; da Silva, E. C. D.; de Aquino, T. M.; da Silva Júnior, E. F. ; de Araújo-Júnior, J. X.; Silva, M. M.; de A. Dantas, M. D.; Santos, J. C. C.; Figueiredo, I. M.; Bazin, M.-A.; Marchand, P.; da Silva, T. G.; Mendonça Junior, F. J. B. 5-Nitro-thiophene-thiosemicarbazone derivatives present antitumor activity mediated by apoptosis and DNA intercalation. Curr. Top. Med. Chem. 2019, 19, 1075-1091.

P23. Barreto Mota, F. V.; Saraiva de Araújo Neta, M.; de Souza Franco, E.; Gomes Alves Bastos, I. V.; Cardoso Correia da Araújo, L.; Cabral da Silva, S.; Bezerra de Oliveira, T.; Souza, E. K.; Moraes de Almeida, V.; Matos Ximenes, R.; de Sousa Maia, M. B.; Mendonça Junior, F. J. B.; Marchand, P.; de Faria, A. R.; da Silva, T. G. Evaluation of anti-inflammatory activity and molecular docking study of new aza-bicyclic isoxazoline acylhydrazone derivatives. Med. Chem. Commun. 2019, 10, 1916-1925.

P22. de Oliveira Pedrosa Rolim, M.; Rodrigues de Almeida, A.; Galdino da Rocha Pitta, M.; Barreto de Melo Rêgo, M. J.; Quintans-Júnior, L. J.; de Souza Siqueira Quintans, J.; Heimfarth, L.; Scotti, L.; Scotti, M. T.; Marques Duarte da Cruz, R.; Nóbrega de Almeida, R.; da Silva, T. G.; de Oliveira, J. A.; de Campos, M. L.; Marchand, P.; Mendonça Junior, F. J. B. Synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent. Int. Immunopharmacol. 2019, 76, 105856; doi:10.1016/j.intimp.2019.105856.

P21. Dallemagne, P.; Rochais, C.; Marchand, P.*; Besson, T. 26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie. Pharmaceuticals - Meeting Report. 2019, 12, 73; doi:10.3390/ph12020073.

P20. Winfield, H. J.; Cahill, M. M.; O’Shea, K. D.; Pierce, L. T.; Robert, T.; Ruchaud, S.; Bach, S.; Marchand, P.; McCarthy, F. O. Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg. Med. Chem. 2018, 26, 4209-2024.

P19. Dao, V. H.; Ourliac-Garnier, I.; Bazin, M.-A.; Jacquot, C.; Baratte, B.; Ruchaud, S.; Bach, S.; Grovel, O.; Le Pape, P.; Marchand, P. Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: synthesis and evaluation of fluconazole susceptibility restoration. Bioorg. Med. Chem. Lett. 2018, 28, 2250-2255.

P18. Reynoso, J. E.; Salgado-Zamora, H.; Bazin, M.-A.; Campos-Aldrete, M. E.; Marchand, P. Design and synthesis of imidazo[1,2-a]pyridines with carboxamide group substitution and in silico evaluation of their interaction with a LuxR-type quorum sensing receptor. J. Heterocycl. Chem. 2018, 55, 1101-1111.

P17. Arruda Lima, S.; Gonçalves Melo, J.; Gadelha Militão, G. C.; Souza Lima, G. M.; Alves Lima, M. C.; Santos Aguiar, J.; Mendonça Araújo, J.; Braz-Filho, R.; Marchand, P.; Araújo, J. M.; Gonçalves Silva, T. Characterization of the biochemical, physiological, and medicinal properties of Streptomyces hygroscopicus ACTMS-9H isolated from the Amazon (Brazil). Appl. Microbiol. Biotechnol. 2017, 101, 711-723.

P16. Bazin, M.-A.; Rousseau, B.; Marhadour, S.; Tomasoni, C.; Evenou, P.; Piessard, S.; Vaisberg, A. J.; Ruchaud, S.; Bach, S.; Roussakis, C.; Marchand, P. Discovery of (imidazo[1,2-a]pyrazin-6-yl)ureas as antiproliferative agents targeting P53 in non-small cell lung cancer cell lines. Anticancer Res. 2016, 36, 1621-1630.

P15. Antoine, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors. Med. Chem. Commun. 2016, 7, 224-229.

P14. Marchand, P.; Bazin, M.-A.; Pagniez, F.; Rivière, G.; Bodero, L.; Marhadour, S.; Nourrisson, M.-R.; Picot, C.; Ruchaud, S.; Bach, S.; Baratte, B.; Sauvain, M.; Castillo Pareja, D.; Vaisberg, A. J.; Le Pape, P. Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines. Eur. J. Med. Chem. 2015, 103, 381-395.

P13. Loidreau, Y.; Deau, E.; Marchand, P.; Nourrisson, M.-R.; Logé, C.; Coadou, G.; Loaëc, N.; Meijer, L.; Besson, T. Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. Eur. J. Med. Chem. 2015, 92, 124-134.

P12. Defaux, J.; Antoine, M.; Logé, C.; Le Borgne, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorg. Med. Chem. Lett. 2014, 24, 3748-3752.

P11. Defaux, J.; Antoine, M.; Le Borgne, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as Aurora kinase inhibitors. ChemMedChem 2014, 9, 217-232.

P10. Deau, E.; Loidreau, Y.; Marchand, P.; Nourrisson, M.-R.; Loaëc, N.; Meijer, L.; Levacher, V.; Besson, T. Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr Kinases. Bioorg. Med. Chem. Lett. 2013, 23, 6784-6788.

P9. Bazin, M.-A.; Bodero, L.; Tomasoni, C.; Rousseau, B.; Roussakis, C.; Marchand, P. Synthesis andantiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines. Eur. J. Med. Chem. 2013, 69, 823-832.

P8. Bazin, M.-A.; Marhadour, S.; Tonnerre, A.; Marchand, P. Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines. Tetrahedron Lett. 2013, 54, 5378-5382.

P7. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Duflos, M.; Loaëc, N.; Meijer, L.; Besson, T. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. Eur. J. Med. Chem. 2013, 59, 283-295.

P6. Loidreau, Y.; Dubouilh-Benard, C.; Marchand, P.; Nourrisson, M.-R.; Duflos, M.; Buquet, C.; Corbière, C.; Besson, T. Efficient new synthesis of N-arylbenzo[b]furo[3,2-d]pyrimidin-4-amines and their benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues via a microwave assisted Dimroth rearrangement. J. Heterocycl. Chem. 2013, 50, 1187-1197.

P5. Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M.-A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P. Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. Eur. J. Med. Chem. 2012, 58, 543-556.

P4. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Duflos, M.; Lozach, O.; Loaec, N.; Meijer, L.; Besson, T. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-aminesand their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. Eur. J. Med. Chem. 2012, 58, 171-183.

P3. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R., Duflos, M.; Besson, T. First synthesis of 4-aminopyrido[2',3':4,5]furo[3,2-d]pyrimidines. Tetrahedron Lett. 2012, 53, 944-947.

P2. Marhadour, S.; Bazin, M.-A.; Marchand, P. An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridine-2-yltriflate through a Suzuki cross-coupling reaction-direct arylation sequence. Tetrahedron Lett. 2012, 53, 297-300.

P1. Antoine, M.; Gerlach, M.; Günther, E.; Schuster, T.; Czech, M.; Seipelt, I.; Marchand, P. A convenient synthesis of novel 2,8-disubstituted pyrido[3,4-b]pyrazines possessing biological activity. Synthesis 2012, 44, 69-82.

Brevets :

Gerlach, M.; Schuster, T.; Marchand, P.; Defaux, J.; Seipelt, I.; Polymeropoulos, E.; Müller, G.; Günther, E. Novel Naphthyridine derivatives and the use thereof as kinase inhibitors. PCT Int. Appl. WO 2011064250, 2011.