P16. Bazin, M.-A.; Rousseau, B.; Marhadour, S.; Tomasoni, C.; Evenou, P.; Piessard, S.; Vaisberg, A. J.; Ruchaud, S.; Bach, S.; Roussakis, C.; Marchand, P. Discovery of (imidazo[1,2-a]pyrazin-6-yl)ureas as antiproliferative agents targeting P53 in non-small cell lung cancer cell lines. Anticancer Res. 2016, 36, 1621-1630.

P15. Antoine, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors. Med. Chem. Commun. 2016, 7, 224-229.

P14. Marchand, P.; Bazin, M.-A.; Pagniez, F.; Rivière, G.; Bodero, L.; Marhadour, S.; Nourrisson, M.-R.; Picot, C.; Ruchaud, S.; Bach, S.; Baratte, B.; Sauvain, M.; Castillo Pareja, D.; Vaisberg, A. J.; Le Pape, P. Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines. Eur. J. Med. Chem. 2015, 103, 381-395.

P13. Loidreau, Y.; Deau, E.; Marchand, P.; Nourrisson, M.-R.; Logé, C.; Coadou, G.; Loaëc, N.; Meijer, L.; Besson, T. Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. Eur. J. Med. Chem. 2015, 92, 124-134.

P12. Defaux, J.; Antoine, M.; Logé, C.; Le Borgne, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorg. Med. Chem. Lett. 2014, 24, 3748-3752.

P11. Defaux, J.; Antoine, M.; Le Borgne, M.; Schuster, T.; Seipelt, I.; Aicher, B.; Teifel, M.; Günther, E.; Gerlach, M.; Marchand, P. Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as Aurora kinase inhibitors. ChemMedChem 2014, 9, 217-232.

P10. Deau, E.; Loidreau, Y.; Marchand, P.; Nourrisson, M.-R.; Loaëc, N.; Meijer, L.; Levacher, V.; Besson, T. Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr Kinases. Bioorg. Med. Chem. Lett. 2013, 23, 6784-6788.

P9. Bazin, M.-A.; Bodero, L.; Tomasoni, C.; Rousseau, B.; Roussakis, C.; Marchand, P. Synthesis andantiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines. Eur. J. Med. Chem. 2013, 69, 823-832.

P8. Bazin, M.-A.; Marhadour, S.; Tonnerre, A.; Marchand, P. Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines. Tetrahedron Lett. 2013, 54, 5378-5382.

P7. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Duflos, M.; Loaëc, N.; Meijer, L.; Besson, T. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. Eur. J. Med. Chem. 2013, 59, 283-295.

P6. Loidreau, Y.; Dubouilh-Benard, C.; Marchand, P.; Nourrisson, M.-R.; Duflos, M.; Buquet, C.; Corbière, C.; Besson, T. Efficient new synthesis of N-arylbenzo[b]furo[3,2-d]pyrimidin-4-amines and their benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues via a microwave assisted Dimroth rearrangement. J. Heterocycl. Chem. 2013, 50, 1187-1197.

P5. Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M.-A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P. Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. Eur. J. Med. Chem. 2012, 58, 543-556.

P4. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Duflos, M.; Lozach, O.; Loaec, N.; Meijer, L.; Besson, T. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-aminesand their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. Eur. J. Med. Chem. 2012, 58, 171-183.

P3. Loidreau, Y.; Marchand, P.; Dubouilh-Benard, C.; Nourrisson, M.-R., Duflos, M.; Besson, T. First synthesis of 4-aminopyrido[2',3':4,5]furo[3,2-d]pyrimidines. Tetrahedron Lett. 2012, 53, 944-947.

P2. Marhadour, S.; Bazin, M.-A.; Marchand, P. An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridine-2-yltriflate through a Suzuki cross-coupling reaction-direct arylation sequence. Tetrahedron Lett. 2012, 53, 297-300.

P1. Antoine, M.; Gerlach, M.; Günther, E.; Schuster, T.; Czech, M.; Seipelt, I.; Marchand, P. A convenient synthesis of novel 2,8-disubstituted pyrido[3,4-b]pyrazines possessing biological activity. Synthesis 2012, 44, 69-82.

Brevet. Gerlach, M.; Schuster, T.; Marchand, P.; Defaux, J.; Seipelt, I.; Polymeropoulos, E.; Müller, G.; Günther, E. Novel Naphthyridine derivatives and the use thereof as kinase inhibitors. PCT Int. Appl. WO 2011064250, 2011.