P242 Castelo-Branco, D.; Lockhart, S. R.; Chen, Y. C.; Santos, D. A.; Hagen, F.; Jane Hawkins, N.; Lavergne, R.-A.; Meis, J.; Le Pape, P.; Gadelha Rocha, F. M.; Julio Costa Sidrim, J.; Arendrup, M.; Morio, F. Collateral consequences of agricultural fungicides on pathogenic yeasts: a One Health perspective to tackle azole resistance. Mycoses 2022, 65, 303–311. doi: 10.1111/myc.13404

P243 Gangneux, J.-P.; Dannaoui, E.; Fekkar, A.; Luyt, C. E.; Botterel, F.; De Prost, N.; Tadié, J.-M.; Reizine, F.; Houzé, S.; Timsit, J.-F.; Iriart, X.; Riu-Poulenc, B.; Sendid, B.; Nseir, S.; Persat, F.; Wallet, F.; Le Pape, P.; Canet, E.; Novara, A.; Manai, M.; Cateau, E.; Thille, A. W.; Brun, S.; Cohen, Y.; Alanio, A.; Mégarbane, B.; Cornet, M.; Terzi, N.; Lamhaut, L.; Sabourin, E.; Desoubeaux, G.; Ehrmann, S.; Hennequin, C.; Voiriot, G.; Nevez, G.; Aubron, C.; Letscher-Bru, V.; Meziani, F.; Blaize, M.; Mayaux, J.; Monsel, A.; Boquel, F.; Robert-Gangneux, F.; Le Tulzo, Y.; Seguin, P.; Guegan, H.; Autier, B.; Lesouhaitier, M.; Pelletier, R.; Belaz, S.; Bonnal, C.; Berry, A.; Leroy, J.; François, N.; Richard, J.-C.; Paulus, S.; Argaud, L.; Dupont, D.; Menotti, J.; Morio, F.; Soulié, M.; Schwebel, C.; Garnaud, C.; Guitard, J.; Le Gal, S.; Quinio, D.; Morcet, J.; Laviolle, B.; Zahar, J. R.; Bougnoux, M.-E. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir. Med. 2022, 10, 180-190. doi: 10.1016/S2213-2600(21)00442-2

P244 Guedes da Silva Almeida, J. R.; Grougnet, R.; Quintans Junior, L. J.; Chevalier, S.; Feuilloley, M.; Robert, T.; Bach, S.; Gonçalves de Oliveira Junior, R.; Thiéry, V.; Bazureau, J.-P.; Mongin, F.; Kritsanida, M.; Sol, V.; de Oliveira Costa, V. C.; Bourgougnon, N.; Marchand, P.; Picot, P. The Franco-Brazilian Network on Natural Products (FB2NP): a new network promoting cooperation and exchanges in natural products research. Letter to the Editor, Quim. Nova 2022, 45, 1-3. doi: 10.21577/0100-4042.20170847

P245 Ceballos-Garzon, A.; Monteoliva, L.; Gil, C.; Alvarez-Moreno, C.; Vega-Vela, N. E.; Engelthaler, D. M.; Bowers, J.; Le Pape, P.; Parra-Giraldo, C. M. Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata. J. Antimicrob. Chemother. 2022, 77, 585–597. doi: 10.1093/jac/dkab454

P246 Lavergne, R.‐A.; Albassier, M.; Hardouin, J.‐B.; Alvarez‐Moreno, C.; Pagniez, F.; Morio, F.; Le Pape, P.; Ourliac‐Garnier, I. Impact of TR34/L98H, TR46/Y121F/T289A and TR53 alterations in azole‐resistant Aspergillus fumigatus on sterol composition and modifications after In Vitro exposure to itraconazole and voriconazole. Microorganisms. 2022, 10, 104. doi.org/10.3390/microorganisms10010104

P247 Muller, T.; Demizieux, L.; Troy-Fioramonti, S.; Buch, C.; Leemput, J.; Belloir, C.; Pais de Barros, J.-P.; Jourdan, T.; Passilly-Degrace, P.; Fioramonti, X.; Le Bon, A.-M.; Vergès, B.; Robert, J.-M.; Degrace, P. Chemical synthesis, pharmacokinetic properties and biological effects of JM-00266, a putative non-brain penetrant cannabinoid receptor 1 inverse agonist. Int. J. Mol. Sci. 2022, 23, 2923. doi: 10.3390/ijms23062923

P248 Ceballos-Garzon, A.; Garcia-Effron, G.; Cordoba, S.; Rodriguez, J.Y.; Alvarez-Moreno, C.; Le Pape, P.; Parra-Giraldo, C.M.; Morales-López, S. Head-to-head comparison of CLSI, EUCAST, Etest and Vitek2 results for Candida auris susceptibility testing. Int. J. Antimicrob. Agents. 2022. doi: 10.1016/j.ijantimicag.2022.106558

P249 Ferraz, T.L.L.; Araújo, E.M.; Calixto, R.F.; Sampaio, M.L.M.; de Mello, L.R.B.; Torres, K.B.; de Aguiar Cordeiro, R.; Le Pape, P.; Gonçalves de Lima-Neto, R. Lethal destructive sinusopathy due to amphotericin B-resistant Aspergillus flavus: A case report. Rev. Iberoam. Micol. 2022. doi: 10.1016/j.riam.2022.01.001

P250 Ceballos-Garzon, A.; Roman, E.; Pla, J.; Pagniez, F.; Amado, D.; Alméciga-Díaz, C.J.; Le Pape, P.; Parra-Giraldo, C.M. CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata. PLoS One 2022. doi: 10.1371/journal.pone.0265777

P251 Mota, F.V.B.; Coutinho, F.N.; de Carvalho, V.M.F.; de Assis Correia, J.C.; Bastos, I.V.G.A.; Neto, P.P.M.; Ximenes, R.M.; Brondani, D.J.; de Faria, A.R.; Marchand, P.; da Silva, T. G. Antinociceptive effects of aza-bicyclic isoxazoline-acylhydrazone derivatives in different models of nociception in mice. Curr. Top. Med. Chem. 2022, 22, 247-258. doi: 10.2174/1568026622666220105102508

P252 Núñez-Mojica, G.; Hernández-Carrillo, M.L.; Avalos-Alanísa, F.G.; Garza-González, E.; Rivas-Galindo, V. M.; Silva-Mares, D.A.; Bazin, M.-A.; Marchand, P.; Camacho-Corona, M.R.* Amino ether analogues of 4,4′-dihydroxy-3-methoxy-6,7′-cyclolignan and their activity against drug-resistant bacteria. Phytochem. Lett. 2022, 50, 57-60. doi: 10.1016/j.phytol.2022.05.004

P253 Libisch, B.; Picot, C.; Ceballos-Garzon, A.; Moravkova, M.; Klimesová, M.; Telkes, G.; Chuang, S.T.; Le Pape, P. Prototheca infections and ecology from a One Health perspective. Microorganisms. 2022, 10, 938. doi: 10.3390/microorganisms10050938

P254 Nourrisson, C.; Moniot, M.; Lavergne, R.A.; Robert, E.; Bonnin, V.; Hagen, F.; Grenouillet, F.; Cafarchia, C.; Butler, G.; Cassaing, S.; Sabou, M.; Le Pape, P.; Poirier, P.; Morio, F. Acquired fluconazole resistance and genetic clustering in Diutina (Candida) catenulata from clinical samples. Clin. Microbiol. Infect. 2022. doi: 10.1016/j.cmi.2022.09.021

P255 Bergin, S.A.; Zhao, F.; Ryan, A.P.; Müller, C.A.; Nieduszynski, C.A.; Zhai, B.; Rolling, T.; Hohl, T.M.; Morio, F.; Scully, J.; Wolfe, K.H.; Butler G. Systematic analysis of copy number variations in the pathogenic yeast Candida parapsilosis identifies a gene amplification in RTA3 that is associated with drug resistance. mBio. 2022, e0177722. doi: 10.1128/mbio.01777-22

P256 Boden, S; Morio, F; Zhou, M; Gerrits van den Ende, B; Hagen, F. De novo nanopore genome sequencing of the clinical Diutina catenulata type-strain CBS565. Mycopathologia. 2022, 187, 417-420. doi: 10.1007/s11046-022-00632-x

P257 Bretagne, S.; Sitbon, K.; Desnos-Ollivier, M.; Garcia-Hermoso, D.; Letscher-Bru, V.; Cassaing, S.; Millon, L.; Morio, F.; Gangneux, J.-P.; Hasseine, L.; Favennec, L.; Cateau, E.; Bailly, E.; Moniot, M.; Bonhomme, J.; Desbois-Nogard, N.; Chouaki, T.; Paugam, A.; Bouteille, B.; Pihet, M.; Dalle, F.; Eloy, O.; Sasso, M.; Demar, M.; Mariani-Kurkdjian, P.; Robert, V.; Lortholary, O.; Dromer, F. French mycoses study group. Active surveillance program to increase awareness on invasive fungal diseases: the French RESSIF network (2012 to 2018). mBio. 2022, e0092022. doi: 10.1128/mbio.00920-22

P258 Le Carpentier, E.C.; Canet E.; Masson D.; Bellouard R.; Grégoire M. Response to "CYP450 3A4/5 Containment During SARS-CoV-2 Infection". Clin. Pharmacol. Ther. 2022, 5:10.1002/cpt.2726. doi: 10.1002/cpt.2726

P259  Le Carpentier E.C.; Canet E.; Masson D.; Martin M.; Deslandes G.; Gaultier A.; Dailly E.; Bellouard R.; Gregoire M. Impact of inflammation on midazolam metabolism in severe COVID-19 Patients. Clin. Pharmacol. Ther. 2022, 1:10.1002/cpt.2698. doi: 10.1002/cpt.2698