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P232 Rodini Garcia Princival, I. M.; Princival, J. L.; Dias da Silva, E.; de Arruda Lima, S. M.; Carvalho Carregosa, J.; Wisniewski Jr, A.; Oliveira de Lucena, C. C.; Halwass, F.; Alves Franca, J. A.; Gomes Rebello Ferreira, L. F.; Zaldini Hernandes, M.; Alcântara Saraiva, K. L.; Alves Peixoto, C.; Baratte, B.; Robert, T.; Bach, S.; Correia Gomes, D.; Guedes Paiva, P. M.; Marchand, P.; do Desterro Rodrigues, M.; Gonçalves da Silva, T. Streptomyces hygroscopicus UFPEDA 3370: a valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells. Chem. Biol. Interact. 2021, 333, 109316. doi: 10.1016/j.cbi.2020.109316

P233 Robert, J.-M. H.; Amoussou, N. G.; Le Mai, H.; Logé, C.; Brouard, S. Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools. Drug Discov. Today. 2021, 26, 56-68. doi: 10.1016/j.drudis.2020.10.022

P234 Núñez-Mojica, G.; Rivas-Galindo, V. M.; Garza-González, E.; Miranda, L. D.; Romo-Pérez, A.; Pagniez, F.; Picot, C.; Le Pape, P.; Bazin, M.-A.; Marchand, P.; Camacho-Corona, M. R. Antimicrobial and anti-leishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl. Med. Chem. Res. 2021, 30, 152-162. doi: 10.1007/s00044-020-02648-8

P235 Iradyan, M.; Iradyan, N.; Sakanyan, V. Allosteric degraders of EGFR leading to cancer cell detachment-promoted death. Atlas of Science. 2021.

P236 D'Agostino, M.; Tesse, N.; Lavergne, R.-A.; Le Pape, P.; Bouchara, J.-P.; Frippiat, J.-P.; Machouart, M.; Debourgogne, A. Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology, J. Glob. Antimicrob. Resist. 2021, 25, 171-180. doi: 10.1016/j.jgar.2021.03.017

P237 Núñez-Mojica, G.; Vázquez-Ramírez, A. L.; García, A.; Rivas-Galindo, V. M.; Garza-González, E.; Cuevas González-Bravo, G. E.; Toscano, R. A.; Moo-Puc, R. E.; Villanueva-Toledo, J. R.; Marchand, P.; Camacho-Corona, M. R. New cyclolignans of Larrea tridentata and their antibacterial and cytotoxic activities. Phytochem. Lett. 2021, 43, 212-218. doi: 10.1016/j.phytol.2021.04.013

P238 Pinet, A.; Cojean, S.; Nguyen, L. T.; Vásquez-Ocmín, P.; Maciuk, A.; Loiseau, P. M.; Le Pape, P.; Figadère, B.; Ferrié, L. Anti-protozoal and anti-fungal evaluation of 3,5-disubstituted 1,2-dioxolanes. Bioorg. Med. Chem. Lett. 2021, 47,  128196. doi: 10.1016/j.bmcl.2021.128196

P239 Rodrigues Oliveira, A.; Alves dos Santos, F.; de Lima Ferreira, L. P.; da Rocha Pitta, M. G.; de Oliveira Silva, M. V.; de Oliveira Cardoso, M. V.; Ferreira Pinto, A.; Marchand, P.; Barreto de Melo Rêgo, M. J.; Lima Leite, A. C. Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives. Chem. Biol. Interact. 2021, 347, 109597. doi: 10.1016/j.cbi.2021.109597

P240 Dao, V. H.; Ourliac-Garnier, I.; Logé, C.; McCarthy, F. O.; Bach, S.; da Silva, T. G.; Denevault-Sabourin, C.; Thiéfaine, J.; Baratte, B.; Robert, T.; Gouilleux, F.; Brachet-Botineau, M.; Bazin M.-A.; Marchand, P. Dibenzofuran derivatives inspired from cercosporamide as dual inhibitors of Pim and CLK1 kinases. Molecules 2021, 26, 6572. doi: 10.3390/molecules26216572

P241 Liu, Q.; Li, S.; Dupuy, A.; Mai, H.l.; Sailliet, N.; Logé, C.; Robert, J.-M.H.; Brouard, S. Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives. Int. J. Mol. Sci. 2021, 22, 7763. doi: 10.3390/ijms22157763