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P232 Rodini Garcia Princival, I. M.; Princival, J. L.; Dias da Silva, E.; de Arruda Lima, S. M.; Carvalho Carregosa, J.; Wisniewski Jr, A.; Oliveira de Lucena, C. C.; Halwass, F.; Alves Franca, J. A.; Gomes Rebello Ferreira, L. F.; Zaldini Hernandes, M.; Alcântara Saraiva, K. L.; Alves Peixoto, C.; Baratte, B.; Robert, T.; Bach, S.; Correia Gomes, D.; Guedes Paiva, P. M.; Marchand, P.; do Desterro Rodrigues, M.; Gonçalves da Silva, T. Streptomyces hygroscopicus UFPEDA 3370: a valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells. Chem. Biol. Interact. 2021, 333, 109316. doi: 10.1016/j.cbi.2020.109316

P233 Robert, J.-M. H.; Amoussou, N. G.; Le Mai, H.; Logé, C.; Brouard, S. Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools. Drug Discov. Today. 2021, 26, 56-68. doi: 10.1016/j.drudis.2020.10.022

P234 Núñez-Mojica, G.; Rivas-Galindo, V. M.; Garza-González, E.; Miranda, L. D.; Romo-Pérez, A.; Pagniez, F.; Picot, C.; Le Pape, P.; Bazin, M.-A.; Marchand, P.; Camacho-Corona, M. R. Antimicrobial and anti-leishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl. Med. Chem. Res. 2021, 30, 152-162. doi: 10.1007/s00044-020-02648-8

P235 Iradyan, M.; Iradyan, N.; Sakanyan, V. Allosteric degraders of EGFR leading to cancer cell detachment-promoted death. Atlas of Science. 2021.

P236 D'Agostino, M.; Tesse, N.; Lavergne, R.-A.; Le Pape, P.; Bouchara, J.-P.; Frippiat, J.-P.; Machouart, M.; Debourgogne, A. Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology, J. Glob. Antimicrob. Resist. 2021, 25, 171-180. doi: 10.1016/j.jgar.2021.03.017

P237 Núñez-Mojica, G.; Vázquez-Ramírez, A. L.; García, A.; Rivas-Galindo, V. M.; Garza-González, E.; Cuevas González-Bravo, G. E.; Toscano, R. A.; Moo-Puc, R. E.; Villanueva-Toledo, J. R.; Marchand, P.; Camacho-Corona, M. R. New cyclolignans of Larrea tridentata and their antibacterial and cytotoxic activities. Phytochem. Lett. 2021, 43, 212-218. doi: 10.1016/j.phytol.2021.04.013

P238 Pinet, A.; Cojean, S.; Nguyen, L. T.; Vásquez-Ocmín, P.; Maciuk, A.; Loiseau, P. M.; Le Pape, P.; Figadère, B.; Ferrié, L. Anti-protozoal and anti-fungal evaluation of 3,5-disubstituted 1,2-dioxolanes. Bioorg. Med. Chem. Lett. 2021, 47,  128196. doi: 10.1016/j.bmcl.2021.128196

P239 Rodrigues Oliveira, A.; Alves dos Santos, F.; de Lima Ferreira, L. P.; da Rocha Pitta, M. G.; de Oliveira Silva, M. V.; de Oliveira Cardoso, M. V.; Ferreira Pinto, A.; Marchand, P.; Barreto de Melo Rêgo, M. J.; Lima Leite, A. C. Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives. Chem. Biol. Interact. 2021, 347, 109597. doi: 10.1016/j.cbi.2021.109597

P240 Dao, V. H.; Ourliac-Garnier, I.; Logé, C.; McCarthy, F. O.; Bach, S.; da Silva, T. G.; Denevault-Sabourin, C.; Thiéfaine, J.; Baratte, B.; Robert, T.; Gouilleux, F.; Brachet-Botineau, M.; Bazin M.-A.; Marchand, P. Dibenzofuran derivatives inspired from cercosporamide as dual inhibitors of Pim and CLK1 kinases. Molecules 2021, 26, 6572. doi: 10.3390/molecules26216572

P241 Castelo-Branco, D.; Lockhart, S. R.; Chen, Y. C.; Santos, D. A.; Hagen, F.; Jane Hawkins, N.; Lavergne, R.-A.; Meis, J.; Le Pape, P.; Gadelha Rocha, F. M.; Julio Costa Sidrim, J.; Arendrup, M.; Morio, F. Collateral consequences of agricultural fungicides on pathogenic yeasts: a One Health perspective to tackle azole resistance. Mycoses 2021. doi: 10.1111/myc.13404

P242 Gangneux, J.-P.; Dannaoui, E.; Fekkar, A.; Luyt, C. E.; Botterel, F.; De Prost, N.; Tadié, J.-M.; Reizine, F.; Houzé, S.; Timsit, J.-F.; Iriart, X.; Riu-Poulenc, B.; Sendid, B.; Nseir, S.; Persat, F.; Wallet, F.; Le Pape, P.; Canet, E.; Novara, A.; Manai, M.; Cateau, E.; Thille, A. W.; Brun, S.; Cohen, Y.; Alanio, A.; Mégarbane, B.; Cornet, M.; Terzi, N.; Lamhaut, L.; Sabourin, E.; Desoubeaux, G.; Ehrmann, S.; Hennequin, C.; Voiriot, G.; Nevez, G.; Aubron, C.; Letscher-Bru, V.; Meziani, F.; Blaize, M.; Mayaux, J.; Monsel, A.; Boquel, F.; Robert-Gangneux, F.; Le Tulzo, Y.; Seguin, P.; Guegan, H.; Autier, B.; Lesouhaitier, M.; Pelletier, R.; Belaz, S.; Bonnal, C.; Berry, A.; Leroy, J.; François, N.; Richard, J.-C.; Paulus, S.; Argaud, L.; Dupont, D.; Menotti, J.; Morio, F.; Soulié, M.; Schwebel, C.; Garnaud, C.; Guitard, J.; Le Gal, S.; Quinio, D.; Morcet, J.; Laviolle, B.; Zahar, J. R.; Bougnoux, M.-E. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir. Med. 2021. doi: 10.1016/S2213-2600(21)00442-2

P243 Guedes da Silva Almeida, J. R.; Grougnet, R.; Quintans Junior, L. J.; Chevalier, S.; Feuilloley, M.; Robert, T.; Bach, S.; Gonçalves de Oliveira Junior, R.; Thiéry, V.; Bazureau, J.-P.; Mongin, F.; Kritsanida, M.; Sol, V.; de Oliveira Costa, V. C.; Bourgougnon, N.; Marchand, P.; Picot, P. The Franco-Brazilian Network on Natural Products (FB2NP): a new network promoting cooperation and exchanges in natural products research. Letter to the Editor, Quim. Nova 2021. http://dx.doi.org/10.21577/0100-4042.20170847

P244 Ceballos-Garzon, A.; Monteoliva, L.; Gil, C.; Alvarez-Moreno, C.; Vega-Vela, N. E.; Engelthaler, D. M.; Bowers, J.; Le Pape, P.; Parra-Giraldo, C. M. Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata. J. Antimicrob. Chemother. 2021. doi: 10.1093/jac/dkab454