P207 Morio, F. Dear medical mycologists, it is time to look outside the box. FEMS Yeast Res. 2020, 20. doi: 10.1093/femsyr/foz080

P208 Pagniez, F.; Lebouvier, N.; Na, Y. M.; Ourliac-Garnier, I.; Picot, C.; Le Borgne, M.; Le Pape, P. Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent. J. Enzym. Inhib. Med. Chem. 2020, 35, 398-403. doi: 10.1080/14756366.2019.1705292

P209 Morio, F.; Lombardi, L.; Butler, G. The CRISPR toolbox in medical mycology: State of the art and perspectives. PLoS Pathog. 2020, 16, e1008201. doi: 10.1371/journal.ppat.1008201

P210 Ceballos-Garzon, A.; Amado, D.; Robert, E.; Parra-Giraldo, C. M.; Le Pape, P. Impact of Calmodulin Inhibition by Fluphenazine on Susceptibility, Biofilm Formation and Pathogenicity of Caspofungin-Resistant Candida glabrata. J. Antimicrob. Chemother. 2020, 75, 1187-1193. doi: 10.1093/jac/dkz565

P211 Ceballos-Garzon, A.; Wintaco-Martínez, L. M.; Velez, N.; Hernandez-Padilla, C.; De la Hoz, A.; Valderrama-Beltrán, S. L.; Alvarez, C. A.; Le Pape, P.; Ramírez, J. D.; Parra-Giraldo, C. Persistence of Clonal Candida albicans azole resistant Isolates from a patient with Chronic Mucocutaneous Candidiasis in Colombia. J. Glob. Infect. Dis. 2020, 12, 16-20. doi: 10.4103/jgid.jgid_74_19

P212 Montoir, D.; Guillon, R.; Gazzola, S.; Ourliac-Garnier, I.; Efouako Soklou, K.; A Tonnerre, A.; Picot, C.; Planchat, A.; Pagniez, F.; Le Pape, P.; Logé, C. New Azole Antifungals with a Fused Triazinone Scaffold. Eur. J. Med. Chem. 2020, 189, 112082. doi: 10.1016/j.ejmech.2020.112082

P213  Glampedakis, E.; Cassaing, S.; Fekkar, A.; Dannaoui, E.; Bougnoux, M.; Bretagne, S.; Neofytos, D.; Schreiber, P.; Hennequin, C.; Morio, F.; Shadrivova, O.; Bongomin, F.; Fernandez Ruiz, M.; Bellanger, A.; Arikan-Akdagli, S.; Erard, V.; Aigner, M.; Paolucci, M.; Charpentier, E.; Bonnal, C.; Brun, S.; Gabriel, F.; Riat, A.; Zbinden, R.; Le Pape, P.; Klimko, N.; Lewis, R.; Richardson, M.; İnkaya, A.; Coste, A.; Lamoth, F. Invasive aspergillosis due to Aspergillus section Usti: a European multi-centre study. Clin. Infect. Dis. 2020, ciaa230. doi: 10.1093/cid/ciaa230

P214 Hoffmann, C.; Guillerm, G.; Le Pape, P.; Carausu, L.; Lavergne, R.-A.; Nevez, G.; Le Gal, S. Mucorales DNA detection in serum specimens for early diagnosis of mucormycosis. Diagn. Microbiol. Infect. Dis. 2020, 115004. doi: 10.1016/j.diagmicrobio.2020.115004

P215 Alvarez-Rueda, N.; Rouges, C.; Touahri, A.; Misme-Aucouturier, B.; Albassier, M.; Le Pape P. In vitro immune responses of human PBMCs against Candida albicans reveals fungal and leucocyte phenotypes associated with fungal persistence. Sci. Rep. 2020, 10, 6211. doi: 10.1038/s41598-020-63344-6

P216 Jeddi, F.; Paugam, C.; Hartuis, S.; Denis-Musquer, M.; Sabou, M.; Lavergne, R.-A.; Muguet, L.; Le Pape, P. Medicopsis romeroi nodular subcutaneous infection in a kidney transplant recipient. Int. J. Infect. Dis. 2020, 95, 262-264. doi: 10.1016/j.ijid.2020.04.028

P217 Morio, F.; O’Brien, C. E.; Butler, G. Draft genome sequence of the yeast Kazachstania telluris CBS 16338, isolated from forest soil in Ireland. Mycopathologia 2020, 185, 587-590. doi: 10.1007/s11046-020-00449-6

P218 Carrara, B.; Richards, R.; Imbert, S.; Morio, F.; Sasso, M.; Zahr, N.; Normand, A.-C.; Le Pape, P.; Lachaud, L.; Ranque, S.; Maubon, D.; Piarroux, R.; Fekkar, A. Species Distribution and Comparison between EUCAST and Gradient Concentration Strips Methods for Antifungal Susceptibility Testing of 112 Aspergillus Section Nigri Isolates. Antimicrob. Agents Chemother. 2020, 64, e02510-19. doi: 10.1128/AAC.02510-19

P219 Loidreau, Y.; Dubouilh-Benard, C.; Nourrisson, M.-R.; Loaëc, N.; Meijer, L.; Besson, T.; Marchand, P. Exploring kinase inhibition properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine derivatives. Pharmaceuticals 2020, 13, 89. doi: 10.3390/ph13050089

P220 Uribe, B.; González, O.; Ourliac-Garnier, I.; Le Pape, P.; Ba, B. B.; Alonso, R.M.; Gaudin, K. Determination of antifungal caspofungin in RPMI-1640 cell culture medium bycolumn-switching HPLC-FLD. J. Pharmaceut. Biomed. 2020, 113366. doi : 10.1016/j.jpba.2020.113366

P221 Papon, N.; Morio, F.; Sanglard, D. Signaling pathways governing the caspofungin paradoxical effect in Aspergillus fumigatus. mBio. 2020, 11, e01816-20. doi: 10.1128/mBio.01816-20

P222 Loidreau, Y.; Nourrisson, M.-R.; Fruit, C.; Corbière, C.; Marchand, P.; Besson, T. Microwave-assisted synthesis of potential bioactive benzo-, pyrido- or pyrazino-thieno[3,2-d]pyrimidin-4-amine analogs of MPC-6827. Pharmaceuticals. 2020, 13, 202. doi: 10.3390/ph13090202

P223 Lebouvier, N.; Pagniez, F.; Na, Y. M.; Shi, D.; Pinson, P.; Marchivie, M.; Guillon, J.; Hakki, T.; Bernhardt, R.; Yee, S. W.; Simons, C.; Lézé, M.-P.; Hartmann, R. W.; Mularoni, A.; Le Baut, G.; Krimm, I.; Abagyan, R.; Le Pape, P.; Le Borgne, M. Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols. Pharmaceuticals. 2020, 13, 186. doi:10.3390/ph13080186

P224 Brochard, J.; Morio, F.; Mahe, J.; Le Pape, P.; Guimard, T.; Mahe, B.; Leterrier, M.; Morrier, M.; Raffi, F.; Boutoille, D. Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis. Med. Mal. Infect. 2020, 50, 742-745. doi: 10.1016/j.medmal.2020.07.005

P225 Bussotti, G.; Benkahla, A.; Jeddi, F.; Souiaï, O.; Aoun, K.; Späth, G. F.; Bouratbine, A. Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype. Microb. Genom. 2020, 6. doi: 10.1099/mgen.0.000444

P226 Bellanger, A. P.; Persat, F.; Foulet, F.; Bonnal, C.; Accoceberry, I.; Angebault, C.; Angoulvant, A.; Augereau, O.; Bailly, E.; Bert, F.; Bonhomme, J.; Bouchara, J. P.; Bougnoux, M. E.; Bourdeau, P.; Bouteille, B.; Brun, S.; Brunet, K.; Camin-Ravenne, A. M.; Cassaing, S.; Chouaki, T.; Cornet, M.; Costa, D.; Desbois, N.; Dorin, J.; Fekkar, A.; Fiacre, A.; Fréalle, E.; Gangneux, J. P.; Guillot, J; Guitard, J.; Hasseine, L.; Huguenin, A.; Lachaud, L.; Larréché, S.; Lavergne, R. A.; Le Gal, S.; Le Govic, Y.; Letscher-Bru, V.; Machouart, M.; Mazars, E.; Nourrisson, C.; Paugam, A.; Ranque, S.; Risco-Castillo, V.; Sasso, M.; Sautour, M.; Sendid, B.; Senghor, Y.; Botterel, F.; Dannaoui, E.. Antifungal susceptibility testing practices in mycology laboratories in France, 2018. J. Mycol. Med. 2020, 30, 100970. doi: 10.1016/j.mycmed.2020.100970

P227 Vargas Casanova, Y.; Villamil Poveda, J. C.;  Rivera Monroy, Z. J.; Ceballos Garzón, A.; Fierro-Medina, R.; Le Pape, P.; García-Castañeda, J. E.; Parra Giraldo, C. M. Palindromic Peptide LfcinB (21-25) Pal Exhibited Antifungal Activity against Multidrug-Resistant Candida. ChemistrySelect. 2020, 5, 7236-7242. doi:10.1002/slct.202001329

P228 Rodriguez, J.Y.; Le Pape, P.; Lopez, O.; Esquea, K.; Labiosa, A.L.; Alvarez-Moreno, C. Candida auris: a latent threat to critically ill patients with COVID-19. Clin. Infect. Dis. 2020, ciaa1595. doi: 10.1093/cid/ciaa1595

P229 Sáenz, V.; Alvarez-Moreno, C.; Le Pape, P.; Restrepo, S.; Guarro, J.; Celis Ramírez.  A.M. A one health perspective to recognize Fusarium as important in clinical practice. J. Fungi. 2020, 6, 235. doi: 10.3390/jof6040235

P230 Chen, J. C.; Munir, M. T.; Aviat, F.; Lepelletier, D.; Le Pape, P.; Dubreil, L.; Irle, M.; Federighi, M.; Belloncle, C.; Eveillard, M.; Pailhoriès, H. Survival of Bacterial Strains on Wood (Quercus petraea) Compared to Polycarbonate, Aluminum and Stainless Steel. Antibiotics, 2020, 9, 804. doi: 10.3390/antibiotics9110804