Bach, S. | IICIMED

Bach, S.

Publications

P300

RSC Med. Chem. 2025, 16, 3746–3763. 

 Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Tisseur, L. | Logé, C. | Cojean, S. | Gassama, K. | Karcher, L. | Pagniez, F. | Cavé, C. | Bernadat, G. | Loiseau, P. M. | Bach, S. | Thiéfaine, J. | Bonnet, J. | Picot, C. | Tomasoni, C. | Leclercq, O. | Baratte, B. | Robert, T. | Le Pape, P. | Rachidi, N. | Bazin, M.-A. | Marchand, P.

https://doi.org/10.1039/D5MD00257E

P290

ChemMedChem. 2025, 20, e202400862.

Investigating the C2 modulation of the imidazo[1,2-a]pyrazine-based hit compound CTN1122: synthesis, in vitro antileishmanial activity, cytotoxicity and casein kinase 1 inhibition.

Tisseur, L. | Cojean, S. | Gassama, K. | Logé, C. | Pagniez, F. | Cavé, C. | Bernadat, G. | Loiseau, P.M. | Bach, S. | Thiéfaine, J. | Picot, C. | Tomasoni, C. | Leclercq, O. | Baratte, B. | Robert, T. | Le Pape, P. | Rachidi, N. | Bazin, M.-A. | Marchand, P.

https://doi.org/10.1002/cmdc.202400862

P285

Int. J. Pharm. Res. Al. Sci. 2024, 13, 1-11.

Design and synthesis of functionalized 2,4-diamino-1,3,5-triazines, potential inhibitors involved in immune and inflammatory response.

Sika Diakite, A. | Ambeu, C. | Yapi, A.D. | Logé, C. | Kacou, A. | Kra, S. | Baratte, B. | Bach, S. | Ruchaud, S. | Sissouma, D. | Ouattara, M. | Robert, J.-M.

https://doi.org/10.51847/hsT2C61XWx

P244

Letter to the Editor, Quim. Nova 2022, 45, 1-3.

The Franco-Brazilian Network on Natural Products (FB2NP): a new network promoting cooperation and exchanges in natural products research. 

Guedes da Silva Almeida, J. R. | Grougnet, R. | Quintans Junior, L. J. | Chevalier, S. | Feuilloley, M. | Robert, T. | Bach, S. | Gonçalves de Oliveira Junior, R. | Thiéry, V. | Bazureau, J.-P. | Mongin, F. | Kritsanida, M. | Sol, V. | de Oliveira Costa, V. C. | Bourgougnon, N. | Marchand, P. | Picot, P.

https://doi.org/10.21577/0100-4042.20170847

P240

Molecules 2021, 26, 6572.

Dibenzofuran derivatives inspired from cercosporamide as dual inhibitors of Pim and CLK1 kinases.

Dao, V. H. | Ourliac-Garnier, I. | Logé, C. | McCarthy, F. O. | Bach, S. | da Silva, T. G. | Denevault-Sabourin, C. | Thiéfaine, J. | Baratte, B. | Robert, T. | Gouilleux, F. | Brachet-Botineau, M. | Bazin, M.-A. | Marchand, P.

doi: 10.3390/molecules26216572

P232

 Chem. Biol. Interact. 2021, 333, 109316. 

Streptomyces hygroscopicus UFPEDA 3370: a valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells.

Rodini Garcia Princival, I. M. | Princival, J. L. | Dias da Silva, E. | de Arruda Lima, S. M. | Carvalho Carregosa, J. | Wisniewski Jr, A. | Oliveira de Lucena, C. C. | Halwass, F. | Alves Franca, J. A. | Gomes Rebello Ferreira, L. F. | Zaldini Hernandes, M. | Alcântara Saraiva, K. L. | Alves Peixoto, C. | Baratte, B. | Robert, T. | Bach, S. | Correia Gomes, D. | Guedes Paiva, P. M. | Marchand, P. | do Desterro Rodrigues, M. | Gonçalves da Silva, T.

doi: 10.1016/j.cbi.2020.109316

P231

Eur. J. Med. Chem. 2021, 210, 112956.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Bazin, M.-A. | Cojean, S. | Pagniez, F. | Bernadat, G. | Cavé, C. | Ourliac-Garnier, I. | Nourrisson, M.-R. | Morgado, C. | Picot, C. | Leclercq, O. | Baratte, B. | Robert, T. | Späth, G.F. | Rachidi, N. | Bach, S. | Loiseau, P.M. | Le Pape, P. | Marchand, P.

doi: 10.1016/j.ejmech.2020.112956

P202

Pharmaceuticals 2019, 12, 169.

Biological evaluation of arylsemicarbazone derivatives as potential anticancer agents.

Nascimento da Cruz, A. C. | Brondani, D .J. | I´talo de Santana, T. | Oliveira da Silva, L. | da Oliveira Borba, E. F. | de Faria, A. R. | Ferreira Cavalcanti de Albuquerque, J. | Piessard, S. | Matos Ximenes, R. | Baratte, B. | Bach, S. | Ruchaud, S. | Bezerra Mendonça Junior, F. J. | Bazin, M.-A. | Montenegro Rabello, M. | Hernandes, M. Z. | Marchand, P. | Gonçalves da Silva, T.

doi:10.3390/ph12040169

P178

Eur. J. Med. Chem. 2018, 154, 101-109.

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.

Oyallon, B. | Brachet-Botineau, M. | Logé, C. | Bonnet, P. | Souab, M. | Robert, T. | Ruchaud, S. | Bach, S. | Berthelot, P. | Gouilleux, F. | Viaud-Massuard, M.-C. | Denevault-Sabourin, C.

doi: 10.1016/j.ejmech.2018.04.056

P177

Bioorg. Med. Chem. 2018, 26, 4209-4224.

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

Winfield, H. J. | Cahill, M. M. | O’Shea, K. D. | Pierce, L. T. | Robert, T. | Ruchaud, S. | Bach, S. | Marchand, P. | McCarthy, F. O.

doi: 10.1016/j.bmc.2018.07.012.

P173

Bioorg. Med. Chem. Lett. 2018, 28, 2250-2255.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: synthesis and evaluation of fluconazole susceptibility restoration.

Dao, V.H. | Ourliac-Garnier, I. | Bazin, M.-A. | Jacquot, C. | Baratte, B. | Ruchaud, S. | Bach, S. | Grovel, O. | Le Pape, P. | Marchand, P.

doi: 10.1016/j.bmcl.2018.05.044

P155

Anticancer Res. 2016, 36, 1621-1630.

Discovery of (imidazo[1,2-a]pyrazin-6-yl)ureas as antiproliferative agents targeting P53 in non-small cell lung cancer cell lines.

Bazin, M.-A. | Rousseau, B. | Marhadour, S. | Tomasoni, C. | Evenou, P. | Piessard, S. | Vaisberg, A. J. | Ruchaud, S. | Bach, S. | Roussakis, C. | Marchand, P.

P142

Eur. J. Med. Chem. 2015, 105, 80-105.

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii Calcium-Dependent Protein Kinase 1.

Moine, E. | Dimier-Poisson, I. | Enguehard-Gueiffier, C. | Logé, C. | Penichon, M. | Moire, N. | Delehouze, C. | Foll-Josselin, B. | Ruchaud, S. | Bach, S. | Gueiffier, A. | Debierre-Grockiego, F. | Denevault-Sabourin, C.

doi: 10.1016/j.ejmech.2015.10.004

P136

Eur. J. Med. Chem. 2015, 103, 381-395.

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

Marchand, P. | Bazin, M.-A. | Pagniez, F. | Rivière, G. | Bodero, L. | Marhadour, S. | Nourrisson, M.-R. | Picot, C. | Ruchaud, S. | Bach, S. | Baratte, B. | Sauvain, M. | Castillo Pareja, D. | Vaisberg, A. J. | Le Pape, P.

doi: 10.1016/j.ejmech.2015.09.002

Autres publications scientifiques

PS36

Pharmaceuticals 2025, 18, 837.

New insights into the anticancer effects and toxicogenomic safety of two β-Lapachone derivatives.

Rivaldo de Lima, J. | Da Silva Góes, A. J. | De Oliveira Borba, E. F. | da Silva, M. A. | Caiana, R. R. A. | do Desterro Rodrigues, M. | De Lima Silva, M. S. | Chagas, C. A. | Baratte, B. | Robert, T. | Bach, S. | Ourliac-Garnier, I. | Marchand, P. | Gonçalves da Silva, T.

https://doi.org/10.3390/ph18060837

PS22

Molbank, 2023 

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23), 9,11,14,16,18,21-octaen-2-yne-15-carboxylate.

Blouet, C. | Letast, S. | Robert, T. | Bach, S. | Pinaud, N. | Joubert, N. | Viaud-Massuard, M.-C. | Guillon, J. | Logé, C. | Denevault-Sabourin, C.

https://doi.org/10.3390/M1735

PS01

Molecules. 2021, 26,867

New quinoxaline derivatives as dual Pim-1/2 inhibitors: design, synthesis and biological evaluation.

Oyallon, B. | Brachet-Botineau, M. | Logé, C. | Robert, T. | Bach, S. | Ibrahim, S. | Raoul, W. | Croix, C. | Berthelot, P. | Gouilleux, F. | Viaud-Massuard, M.-C. | Denevault-Sabourin, C.

https://doi.org/10.3390/molecules26040867

Brevets

Thèse