Marchand, P.

Professor - Head of Department

Publications

P312

ChemMedChem 2026, 21, e70338.

Bicyclic Lactams From Chiral Imines: Synthesis, Structural Optimization, and Biological Evaluation of Promising Antileishmanial Agents.

Sagne, S. Cojean, S. Diallo, R. O. Barbosa, E.G. Weber, K.C. da Silva, M.C. Sambou, O. Tomasoni, C. Bonnet, J. Pagniez, F. Cavé, C. Gassama, A Marchand, P.

https://doi.org/10.1002/cmdc.70338

P310

Bioorg. Chem. 2026, 176, 109839.

Insights into a new class of antileishmanial compounds: an in vitro and in silico study of 1,2,4-oxadiazol-5(4H)-one derivatives.

Maciel, L-G. dos Anjos, J. V. De Sousa, J.M.S. de Souza, V. M. R. Sousa, M. G. G. S. Viana, J. O. Bezerra França, S. Barbosa, E.G. Weber, K.C. Rodrigues, K.A.d.F. Mendonça Junior, F. J. B. Aquino, T. M. da Silva, T. G. Marchand, P.

https://doi.org/10.1016/j.bioorg.2026.109839

P309

Bioorg. Med. Chem. 2026, 139, 118678.

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-based thiosemicarbazones as anti-Trypanosoma cruzi agents.

Saraiva de Araujo Neta, M. Coelho, M-C. Coutinho, F. N. Alves Pereira, V. R. Hernandes, M. Z. Ferreira, R. S. Sales Junior, P. A. Murta, S. M. F. Ourliac-Garnier, I. Bazin, M.-A. Courtioux, B. Boudot, C. Santos, A. C. da S. Gomes Rebello Ferreira, L. F. Martins, L. C. Thiéfaine, J. Brenot, E. Mendonça Junior, F. J. B. da Silva, T. G. de Faria, A. R. Marchand, P.

https://doi.org/10.1016/j.bmc.2026.118678

P300

RSC Med. Chem. 2025, 16, 3746–3763. 

 Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Tisseur, L. Logé, C. Cojean, S. Gassama, K. Karcher, L. Pagniez, F. Cavé, C. Bernadat, G. Loiseau, P. M. Bach, S. Thiéfaine, J. Bonnet, J. Picot, C. Tomasoni, C. Leclercq, O. Baratte, B. Robert, T. Le Pape, P. Rachidi, N. Bazin, M.-A. Marchand, P.

https://doi.org/10.1039/D5MD00257E

P290

ChemMedChem. 2025, 20, e202400862.

Investigating the C2 modulation of the imidazo[1,2-a]pyrazine-based hit compound CTN1122: synthesis, in vitro antileishmanial activity, cytotoxicity and casein kinase 1 inhibition.

Tisseur, L. Cojean, S. Gassama, K. Logé, C. Pagniez, F. Cavé, C. Bernadat, G. Loiseau, P.M. Bach, S. Thiéfaine, J. Picot, C. Tomasoni, C. Leclercq, O. Baratte, B. Robert, T. Le Pape, P. Rachidi, N. Bazin, M.-A. Marchand, P.

https://doi.org/10.1002/cmdc.202400862

P289

Pharmaceuticals. 2025, 18, 125.

2-Aminothiophene derivatives -New drug canditates against leismaniasis: Drug design, synthesis, pharmacomodulation, and antileishmanial activity.

de Araujo, R.S.A. Bernardo, V.G. Tiburcio, R.d.S. Bedor, D.C.G. Campos, M.L.d. Pontarolo, R. De Sousa, J.M.S. Rodrigues, K.A.d.F. Scotti, M.T. Nayarisseri, A. Marchand, P. Mendonça-Junior, F.J.B.

https://doi.org/10.3390/ph18010125

P287

Eur. J. Med. Chem. Rep. 2024, 12, 100228.

Biological properties and in silico studies of thiazolopyrimidine derivatives active against visceral and cutaneous Leishmania spp. amastigote forms.

Bayaraktar, G. Marchand, P. Barbosa, E.G. da Silva, M.C. Weber, K.C. Cojean, S. Saylam, M. Istanbullu, H.

https://doi.org/10.1016/j.ejmcr.2024.100228.

P279

Pharmaceuticals 2024, 17, 516.

FRET Assays for the Identification of C. albicans HSP90-Sba1 and Human HSP90α-p23 Binding Inhibitors.

Kohlmann, P. Krylov, S.-N. Marchand, P. Jose, J.

https://doi.org/10.3390/ph17040516

P275

Microorganisms 2023, 11, 2837. 

Is the C-terminal domain an effective and selective target for the design of Hsp90 inhibitors against Candida yeast?

Rouges, C. Asad, M. Laurent, A.D. Marchand, P. Le Pape, P.

https://doi.org/10.3390/microorganisms11122837

P269

Nat. Prod. Res. 2023

Phytochemical, antileishmanial, antifungal and cytotoxic profiles of Thymelaea tartonraira (L.) All. extracts.

Soltani,S Koubaa, I. Cojean, S. Picot, C. Marchand, P. Allouche, N.

https://doi.org/10.1080/14786419.2023.2252153

P268

Future Microbiol. 2023, 18, 1225-1233.

Antifungal efficacy of imidazo[1,2-a]pyrazine based thiosemicarbazones and thiazolidinediones against Sporothrix species.

Gonçalves de Lima Neto, R. Saraiva de Araújo Neta, M. Tiburcio Valeriano, C. A. Pereira Neves, R. Lacerda, A. M. Ferraz, C. E. Inácio, C. P. Le Pape, P. Ourliac-Garnier, I. de Faria, A. R. da Silva, T. G. Alves Pereira, V. R. Marchand, P.

https://doi.org/10.2217/fmb-2023-0044

P267

Chem. Biodivers. 2023, 20, e202200944;

New specific α-glucosidase inhibitor flavonoid from Thymelaea tartonraira leaves: structure elucidation, biological and molecular docking studies.

Soltani, S. Koubaa, I. Dhouib, I. Khemakham, B. Marchand, P. Allouche, N.

https://doi.org/10.1002/cbdv.202200944

P250

Phytochem. Lett. 2022, 50, 57-60.

Amino ether analogues of 4,4′-dihydroxy-3-methoxy-6,7′-cyclolignan and their activity against drug-resistant bacteria. 

Núñez-Mojica, G. Hernández-Carrillo, M. L. Avalos-Alanísa, F. G. Garza-González, E. Rivas-Galindo, V. M. Silva-Mares, D. A. Bazin, M.-A. Marchand, P. Camacho-Corona, M.R.

https://doi.org/10.1016/j.phytol.2022.05.004

P244

Letter to the Editor, Quim. Nova 2022, 45, 1-3.

The Franco-Brazilian Network on Natural Products (FB2NP): a new network promoting cooperation and exchanges in natural products research. 

Guedes da Silva Almeida, J. R. Grougnet, R. Quintans Junior, L. J. Chevalier, S. Feuilloley, M. Robert, T. Bach, S. Gonçalves de Oliveira Junior, R. Thiéry, V. Bazureau, J.-P. Mongin, F. Kritsanida, M. Sol, V. de Oliveira Costa, V. C. Bourgougnon, N. Marchand, P. Picot, P.

https://doi.org/10.21577/0100-4042.20170847

P240

Molecules 2021, 26, 6572.

Dibenzofuran derivatives inspired from cercosporamide as dual inhibitors of Pim and CLK1 kinases.

Dao, V. H. Ourliac-Garnier, I. Logé, C. McCarthy, F. O. Bach, S. da Silva, T. G. Denevault-Sabourin, C. Thiéfaine, J. Baratte, B. Robert, T. Gouilleux, F. Brachet-Botineau, M. Bazin, M.-A. Marchand, P.

doi: 10.3390/molecules26216572

P239

Chem. Biol. Interact. 2021, 347, 109597.

Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives.

Rodrigues Oliveira, A. Alves dos Santos, F. de Lima Ferreira, L. P. da Rocha Pitta, M. G. de Oliveira Silva, M. V. de Oliveira Cardoso, M. V. Ferreira Pinto, A. Marchand, P. Barreto de Melo Rêgo, M. J. Lima Leite, A. C.

doi: 10.1016/j.cbi.2021.109597

P237

Phytochem. Lett. 2021, 43, 212-218.

New cyclolignans of Larrea tridentata and their antibacterial and cytotoxic activities.

Núñez-Mojica, G. Vázquez-Ramírez, A. L. García, A. Rivas-Galindo, V. M. Garza-González, E. Cuevas González-Bravo, G. E. Toscano, R. A. Moo-Puc, R. E. Villanueva-Toledo, J. R. Marchand, P. Camacho-Corona, M. R.

doi: 10.1016/j.phytol.2021.04.013

P234

Med. Chem. Res. 2021, 30, 152-162.

Antimicrobial and anti-leishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl.

Núñez-Mojica, G. Rivas-Galindo, V. M. Garza-González, E. Miranda, L. D. Romo-Pérez, A. Pagniez, F. Picot, C. Le Pape, P. Bazin, M.-A. Marchand, P. Camacho-Corona, M. R.

doi: 10.1007/s00044-020-02648-8

P232

 Chem. Biol. Interact. 2021, 333, 109316. 

Streptomyces hygroscopicus UFPEDA 3370: a valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells.

Rodini Garcia Princival, I. M. Princival, J. L. Dias da Silva, E. de Arruda Lima, S. M. Carvalho Carregosa, J. Wisniewski Jr, A. Oliveira de Lucena, C. C. Halwass, F. Alves Franca, J. A. Gomes Rebello Ferreira, L. F. Zaldini Hernandes, M. Alcântara Saraiva, K. L. Alves Peixoto, C. Baratte, B. Robert, T. Bach, S. Correia Gomes, D. Guedes Paiva, P. M. Marchand, P. do Desterro Rodrigues, M. Gonçalves da Silva, T.

doi: 10.1016/j.cbi.2020.109316

P231

Eur. J. Med. Chem. 2021, 210, 112956.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Bazin, M.-A. Cojean, S. Pagniez, F. Bernadat, G. Cavé, C. Ourliac-Garnier, I. Nourrisson, M.-R. Morgado, C. Picot, C. Leclercq, O. Baratte, B. Robert, T. Späth, G.F. Rachidi, N. Bach, S. Loiseau, P.M. Le Pape, P. Marchand, P.

doi: 10.1016/j.ejmech.2020.112956

Autres publications scientifiques

PS38

J. Med. Chem. 2025, 68, 2045–2047.

Shaping future medicinal chemists: Perspectives from European schools of Pharmacy within the GP2A network.

Bayaraktar, G. Carro, L. Decker, M. Giuntini, F. Helesbeux, J.J Marchand, P. Matthews, S. E. McCarthy, F. O. Mistry, S. N. Moreira, V. M. O'Boyle, N. M. Pace, V. Rochais, C. Saylam, M. Sotelo, E.

https://doi.org/10.1021/acs.jmedchem.4c03103

PS37

Pharmaceuticals 2025, 18, 837.

New insights into the anticancer effects and toxicogenomic safety of two β-Lapachone derivatives.

Rivaldo de Lima, J. Da Silva Góes, A. J. De Oliveira Borba, E. F. da Silva, M. A. Caiana, R. R. A. do Desterro Rodrigues, M. De Lima Silva, M. S. Chagas, C. A. Baratte, B. Robert, T. Bach, S. Ourliac-Garnier, I. Marchand, P. Gonçalves da Silva, T.

https://doi.org/10.3390/ph18060837

PS09

Antiinflamm. Antiallergy Agents Med. Chem. 2022, 21, 135-151. 

Effects of acylhydrazone derivatives on experimental pulmonary inflammation by chemical sensitization.

de Lima Porto Ramos, K. R. Cabral da Silva, S. Marchand, P. Barreto Mota, F. V. de Assis Correia, J. C. Gomes da Silva, J. A. Santana, M. A. da Silva Moura, W. C. dos Santos, V. L. Moura, R. O. da Silva, T. G.

https://doi.org/10.2174/1871523021666220729141608

PS04

Curr. Top. Med. Chem. 2022, 22, 247-258. 

Antinociceptive effects of aza-bicyclic isoxazoline-acylhydrazone derivatives in different models of nociception in mice.

Mota, F. V. B. Coutinho, F. N. de Carvalho, V. M. F. de Assis Correia, J. C. Bastos, I. V. G. A. Neto, P. P. M. Ximenes, R. M. Brondani, D. J. de Faria, A. R. Marchand, P. da Silva, T. G.

https://doi.org/10.2174/1568026622666220105102508

Brevets

B12.

Nouveaux dérivés indoliques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Marchand, P. Babonneau, V. Piessard, S. Duflos, M. Boutin, J.A. Audinot, V. Delagrange, P. Caignard, D-H.

Brevet Français, déposé le 18 octobre 2006, sous le n° 06/09114.

B11.

Nouveaux dérivés indoliques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Marchand, P. Babonneau, V. Piessard, S. Duflos, M. Boutin, J.A. Audinot, V. Delagrange, P. Caignard, D-H.

Brevet Français, déposé le 18 octobre 2006, sous le n° 06/09113.

B15.

Novel Naphthyridine derivatives and the use thereof as kinase inhibitors.

Gerlach, M. Schuster, T. Marchand, P. Defaux, J. Seipelt, I. Polymeropoulos, E. Müller, G. Günther, E.

PCT Int. Appl. WO 2011064250, 2011.

Thèse

T01.

Synthèse et évaluation pharmacologique de dérivés indoliques à activités immunosuppressive et antitumorale.

Marchand, P.

Nantes, 23 novembre 1999.