P302

Inorg. Chem., 2025, 64, 16192-16203.

Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold.

Zhong, S. Kalamatianou, A. Scalese, G. O'Beirne, C. Redrado, M. Blacque, O. Picot, C. Tomasoni, C. Logé, C. Albassier, M. Ourliac-Garnier, I. Pagniez, F. Le Pape, P. Pérez-Díaz, L. Gambino, D. Comini, M. A. Cariou, K. Gasser, G.

https://doi.org/10.1021/acs.inorgchem.5c02730

P300

RSC Med. Chem. 2025, 16, 3746–3763.

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Tisseur, L. Logé, C. Cojean, S. Gassama, K. Karcher, L. Pagniez, F. Cavé, C. Bernadat, G. Loiseau, P. M. Bach, S. Thiéfaine, J. Bonnet, J. Picot, C. Tomasoni, C. Leclercq, O. Baratte, B. Robert, T. Le Pape, P. Rachidi, N. Bazin, M.-A. Marchand, P.

https://doi.org/10.1039/D5MD00257E

P290

ChemMedChem. 2025, 20, e202400862.

Investigating the C2 modulation of the imidazo[1,2-a]pyrazine-based hit compound CTN1122: synthesis, in vitro antileishmanial activity, cytotoxicity and casein kinase 1 inhibition.

Tisseur, L. Cojean, S. Gassama, K. Logé, C. Pagniez, F. Cavé, C. Bernadat, G. Loiseau, P.M. Bach, S. Thiéfaine, J. Picot, C. Tomasoni, C. Leclercq, O. Baratte, B. Robert, T. Le Pape, P. Rachidi, N. Bazin, M.-A. Marchand, P.

https://doi.org/10.1002/cmdc.202400862

P280

Chem. Biodiversity 2024, e202300563

Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Morrocan Thymus capitatus Essential Oil.

Amakran, A. Hamoudane, M. Pagniez, F. Lamarti, A. Picot, C. Figueredo, G. Nhiri, M. Le Pape, P.

https://doi.org/10.1002/cbdv.202300563

P270

J. Fungi 2023, 9, 430.

The mortality attributable to candidemia in C. auris is higher than that in other Candida species: Myth or reality?

Alvarez-Moreno, CA. Morales-López, S. Rodriguez, G. J. Rodriguez, J. Y. Robert, E. Picot, C. Ceballos-Garzon, A. Parra-Giraldo, C. M. Le Pape, P.

https://doi.org/10.3390/jof9040430

P269

Nat. Prod. Res. 2023

Phytochemical, antileishmanial, antifungal and cytotoxic profiles of Thymelaea tartonraira (L.) All. extracts.

Soltani,S Koubaa, I. Cojean, S. Picot, C. Marchand, P. Allouche, N.

https://doi.org/10.1080/14786419.2023.2252153

P251

Microorganisms. 2022, 10, 938.

Prototheca infections and ecology from a One Health perspective.

Libisch, B. Picot, C. Ceballos-Garzon, A. Moravkova, M. Klimesová, M. Telkes, G. Chuang, S.T. Le Pape, P.

https://doi.org/10.3390/microorganisms10050938

P234

Med. Chem. Res. 2021, 30, 152-162.

Antimicrobial and anti-leishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl.

Núñez-Mojica, G. Rivas-Galindo, V. M. Garza-González, E. Miranda, L. D. Romo-Pérez, A. Pagniez, F. Picot, C. Le Pape, P. Bazin, M.-A. Marchand, P. Camacho-Corona, M. R.

doi: 10.1007/s00044-020-02648-8

P231

Eur. J. Med. Chem. 2021, 210, 112956.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Bazin, M.-A. Cojean, S. Pagniez, F. Bernadat, G. Cavé, C. Ourliac-Garnier, I. Nourrisson, M.-R. Morgado, C. Picot, C. Leclercq, O. Baratte, B. Robert, T. Späth, G.F. Rachidi, N. Bach, S. Loiseau, P.M. Le Pape, P. Marchand, P.

doi: 10.1016/j.ejmech.2020.112956

P212

Eur. J. Med. Chem. 2020, 189, 112082.

New Azole Antifungals with a Fused Triazinone Scaffold.

Montoir, D. Guillon, R. Gazzola, S. Ourliac-Garnier, I. Efouako Soklou, K. A Tonnerre, A. Picot, C. Planchat, A. Pagniez, F. Le Pape, P. Logé, C.

doi: 10.1016/j.ejmech.2020.112082

P208

J. Enzym. Inhib. Med. Chem. 2020, 35, 398-403.

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent.

Pagniez, F. Lebouvier, N. Na, Y. M. Ourliac-Garnier, I. Picot, C. Le Borgne, M. Le Pape, P.

doi: 10.1080/14756366.2019.1705292

P136

Eur. J. Med. Chem. 2015, 103, 381-395.

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

Marchand, P. Bazin, M.-A. Pagniez, F. Rivière, G. Bodero, L. Marhadour, S. Nourrisson, M.-R. Picot, C. Ruchaud, S. Bach, S. Baratte, B. Sauvain, M. Castillo Pareja, D. Vaisberg, A. J. Le Pape, P.

doi: 10.1016/j.ejmech.2015.09.002

P114

ACS Med. Chem. Lett., 2013, 4, 288-292.

Discovery of a novel broad-spectrum antifungal agent, derived from albaconazole.

Guillon, R. Pagniez, F. Picot, C. Hédou, D. A. Tonnerre, A. Chosson, E. Duflos, M. Besson, T. Logé, C. Le Pape, P.

P108

Eur. J. Med. Chem., 2012, 58, 543-556.

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.

Marhadour, S. Marchand, P. Pagniez, F. Bazin, M.-A. Picot, C. Lozach, O. Ruchaud, S. Antoine, M. Meijer, L. Rachidi, N. Le Pape, P.

P96

ChemMedChem, 2011, 6, 1806-1815.

Design, synthesis and biological evaluation of 1-[(biarylmethyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as potent antifungal agents: new insights into structure-activity relationships.

Guillon, R. Pagniez, F. Rambaud, C. Picot, C. Duflos, M. Logé, C. Le Pape, P.

P91

ChemMedChem, 2011, 6, 816-825.

Design, synthesis and in vitro antifungal activity of 1-[(4-substituted benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Guillon, R. Pagniez, F. Logé, C. Giraud, F. Crépin, D. Picot, C. Le Borgne, M. Morio, F. Duflos, M. Le Pape, P.

P87

J. Enzym. Inhib. Med. Chem., 2011, 26(2), 261-269.

Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Guillon, R. Logé C. Pagniez, F. Ferchaud-Roucher, V. Duflos, M. Picot, C. Le Pape, P.

P79

Bioorg. Med. Chem. Lett., 2009, 19(20), 5833-5836.

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Guillon, R. Giraud, F. Logé, C. Le Borgne, M. Picot, C. Pagniez, F. Le Pape, P.

P77

J. Enz. Inh. Med. Chem., 2009, 24(5), 1067-1075.

Design, synthesis and evaluation of 3-(imidazol-1-ylmethyl)indoles as antileishmanial agents. Part II.

Giraud, F. Logé, C. Pagniez, F. Crépin, D. Barres, S. Picot, C. Le Pape, P. Le Borgne, M.

P74

Bioorg. Med. Chem. Lett., 2009, 19(2), 301-304

Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.

Giraud, F. Guillon, R. Logé, C. Pagniez, F. Picot, C. Le Borgne, M. Le Pape, P.