Le Pape, P. | IICIMED

Le Pape, P.

Professeur – Praticien Hospitalier - Responsable de département

Publications

P302

Inorg. Chem., 2025, 64, 16192-16203. 

Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold.

Zhong, S. | Kalamatianou, A. | Scalese, G. | O'Beirne, C. | Redrado, M. | Blacque, O. | Picot, C. | Tomasoni, C. | Logé, C. | Albassier, M. | Ourliac-Garnier, I. | Pagniez, F. | Le Pape, P. | Pérez-Díaz, L. | Gambino, D. | Comini, M. A. | Cariou, K. | Gasser, G.

https://doi.org/10.1021/acs.inorgchem.5c02730

P301

J. Med. Mycol. 2025, 101583.

A One Health Perspective on Diutina catenulata: Phenotypic Traits, Stress Sensitivity, and Virulence Across Diverse Isolates.

Prudencio de Albuquerque, I. K. | Morio, F. | Albassier, M. | Baron, L. | Duchesne, L. | Le Pape, P. | Ourliac-Garnier, I.

https://doi.org/10.1016/j.mycmed.2025.101583

P300

RSC Med. Chem. 2025, 16, 3746–3763. 

 Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Tisseur, L. | Logé, C. | Cojean, S. | Gassama, K. | Karcher, L. | Pagniez, F. | Cavé, C. | Bernadat, G. | Loiseau, P. M. | Bach, S. | Thiéfaine, J. | Bonnet, J. | Picot, C. | Tomasoni, C. | Leclercq, O. | Baratte, B. | Robert, T. | Le Pape, P. | Rachidi, N. | Bazin, M.-A. | Marchand, P.

https://doi.org/10.1039/D5MD00257E

P291

Mycoses. 2025, 68, e70085.

Clade Distinction and Tracking of Clonal Spread by Fourier-Transform Infrared Spectroscopy in Multicenter candida (Candidozyma) auris Ourbreak.

De Melo, C. C. | Lima de Oliveira, H. | Souza, B. R. | Moura, C. V. R. | Oliveira, R. | Bastos, R. W. | Kemmerich, K. | De Almeida-Junior, J. N. | Lopes Colombo, A. | Spruitjenburg, B. | Meis, J.-F. | Le Pape, P. | Moonen, C. G. J. | De Lima-Neto, R. G.

https://doi.org/10.1111/myc.70085

P290

ChemMedChem. 2025, 20, e202400862.

Investigating the C2 modulation of the imidazo[1,2-a]pyrazine-based hit compound CTN1122: synthesis, in vitro antileishmanial activity, cytotoxicity and casein kinase 1 inhibition.

Tisseur, L. | Cojean, S. | Gassama, K. | Logé, C. | Pagniez, F. | Cavé, C. | Bernadat, G. | Loiseau, P.M. | Bach, S. | Thiéfaine, J. | Picot, C. | Tomasoni, C. | Leclercq, O. | Baratte, B. | Robert, T. | Le Pape, P. | Rachidi, N. | Bazin, M.-A. | Marchand, P.

https://doi.org/10.1002/cmdc.202400862

P286

J. Mycol. Med. 2024, 34, 101490.

Current knowledge and practice of Candida auris screening in France: A nationwide survey from the French Society of Medical Mycology (SFMM).

Guitard, J. | Bellanger, A.P. | Dorin, J. | Cassaing, S. | Capitaine, A. | Gabriel, F. | Nicolas, M. | Coron, N. | Penn, P. | Moniot, M. | Quinio, D. | Ranque, S. | Sasso, M. | Le Pape, P. | Dannaoui, E. | Brun, S. | Lacroix, C. | Cornu, M. | Debourgogne, A. | Durieux, M.F. | Laurent, G. | Bru, V. | Bourgeois, N. | Brunet, K. | Chouaki, T. | Huguenin, A. | Hasseine, L. | Maubon, D. | Gangneux, J.P. | Desbois-Nogard, N. | Houze, S. | Dalle, F. | Bougnoux, M.E. | Alanio, A. | Costa, D. | Botterel, F. | Hennequin, C.

https://doi.org/10.1016/j.mycmed.2024.101490

P280

Chem. Biodiversity 2024, e202300563

Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Morrocan Thymus capitatus Essential Oil.

Amakran, A. | Hamoudane, M. | Pagniez, F. | Lamarti, A. | Picot, C. | Figueredo, G. | Nhiri, M. | Le Pape, P.

https://doi.org/10.1002/cbdv.202300563

P278

Antimicrob. Agents Chemother. 2024, e0002224.

Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis.

Hartuis, S. | Ourliac-Garnier, I. | Robert, E. | Albassier, M. | Duchesne, L. | Beaufils, C. | Kuhn, J. | Le Pape, P. | Morio, F.

https://doi.org/10.1128/aac.00022-24

P275

Microorganisms 2023, 11, 2837. 

Is the C-terminal domain an effective and selective target for the design of Hsp90 inhibitors against Candida yeast?

Rouges, C. | Asad, M. | Laurent, A.D. | Marchand, P. | Le Pape, P.

https://doi.org/10.3390/microorganisms11122837

P271

J. Med. Chem. 2023.

Discovery of new broad-spectrum anti-infectives for eukaryotic pathogens using boorganometallic chemistry. 

Lin, Y. | Jung, H. | Bulman, C. A. | Ng, J. | Vinck, R. | O'Beirne, C. | Moser, M. S. | Tricoche, N. | Peguero, R. | Li, R. W. | Urban, J. F. | Le Pape, P. | Pagniez, F. | Moretto, M. | Weil, T. | Lustigman, S. | Cariou, K. | Mitreva, M. | Sakanari, J. A. | Gasser, G.

https://doi.org/10.1021/acs.jmedchem.3c01333

P270

J. Fungi 2023, 9, 430.

The mortality attributable to candidemia in C. auris is higher than that in other Candida species: Myth or reality? 

Alvarez-Moreno, CA. | Morales-López, S. | Rodriguez, G. J. | Rodriguez, J. Y. | Robert, E. | Picot, C. | Ceballos-Garzon, A. | Parra-Giraldo, C. M. | Le Pape, P.

https://doi.org/10.3390/jof9040430

P268

Future Microbiol. 2023, 18, 1225-1233.

Antifungal efficacy of imidazo[1,2-a]pyrazine based thiosemicarbazones and thiazolidinediones against Sporothrix species.

Gonçalves de Lima Neto, R. | Saraiva de Araújo Neta, M. | Tiburcio Valeriano, C. A. | Pereira Neves, R. | Lacerda, A. M. | Ferraz, C. E. | Inácio, C. P. | Le Pape, P. | Ourliac-Garnier, I. | de Faria, A. R. | da Silva, T. G. | Alves Pereira, V. R. | Marchand, P.

https://doi.org/10.2217/fmb-2023-0044

P258

Future Microbiol. 2022, 17, 1437-1443. 

Otomycosis caused by the cryptic and emerging species Aspergillus sydowii: two case reports.

Buonafina-Paz, M. D. | Santos, F. A. | Leite-Andrade, M. C. | Alves, AI. | Bezerra, J. D. | Leal, M. C. | Robert, E. | Le Pape, P. | Lima-Neto, R. G. | Neves, R. P.

https://doi.org/10.2217/fmb-2022-0137

P252

Clin. Microbiol. Infect. 2022. 

Acquired fluconazole resistance and genetic clustering in Diutina (Candida) catenulata from clinical samples.

Nourrisson, C. | Moniot, M. | Lavergne, R.A. | Robert, E. | Bonnin, V. | Hagen, F. | Grenouillet, F. | Cafarchia, C. | Butler, G. | Cassaing, S. | Sabou, M. | Le Pape, P. | Poirier, P. | Morio, F.

https://doi.org/10.1016/j.cmi.2022.09.021

P251

Microorganisms. 2022, 10, 938.

Prototheca infections and ecology from a One Health perspective. 

Libisch, B. | Picot, C. | Ceballos-Garzon, A. | Moravkova, M. | Klimesová, M. | Telkes, G. | Chuang, S.T. | Le Pape, P.

https://doi.org/10.3390/microorganisms10050938

P249

PLoS One 2022. 

CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata. 

Ceballos-Garzon, A. | Roman, E. | Pla, J. | Pagniez, F. | Amado, D. | Alméciga-Díaz, C. J. | Le Pape, P. | Parra-Giraldo, C. M.

https://doi.org/10.1371/journal.pone.0265777

P248

Rev. Iberoam. Micol. 2022.

Lethal destructive sinusopathy due to amphotericin B-resistant Aspergillus flavus: A case report. 

Ferraz, T. L. L. | Araújo, E. M. | Calixto, R. F. | Sampaio, M. L. M. | de Mello, L. R. B. | Torres, K. B. | de Aguiar Cordeiro, R. | Le Pape, P. | Gonçalves de Lima Neto, R.

https://doi.org/10.1016/j.riam.2022.01.001

P247

Int. J. Antimicrob. Agents. 2022. 

Head-to-head comparison of CLSI, EUCAST, Etest and Vitek2 results for Candida auris susceptibility testing.

Ceballos-Garzon, A. | Garcia-Effron, G. | Cordoba, S. | Rodriguez, J. Y. | Alvarez-Moreno, C. | Le Pape, P. | Parra-Giraldo, C. M. | Morales-López, S.

https://doi.org/10.1016/j.ijantimicag.2022.106558

P246

Microorganisms. 2022, 10, 104. 

Impact of TR34/L98H, TR46/Y121F/T289A and TR53 alterations in azole‐resistant Aspergillus fumigatus on sterol composition and modifications after In Vitro exposure to itraconazole and voriconazole.

Lavergne, R.-A. | Albassier, M. | Hardouin, J.‐B. | Alvarez‐Moreno, C. | Pagniez, F. | Morio, F. | Le Pape, P. | Ourliac-Garnier, I.

https://doi.org/10.3390/microorganisms10010104

P245

J. Antimicrob. Chemother. 2022, 77, 585–597. 

Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata.

Ceballos-Garzon, A. | Monteoliva, L. | Gil, C. | Alvarez-Moreno, C. | Vega-Vela, N. E. | Engelthaler, D. M. | Bowers, J. | Le Pape, P. | Parra-Giraldo, C. M.

https://doi.org/10.1093/jac/dkab454

Autres publications scientifiques

PS07

Antimicrob. Agents Chemother. 2022, 66, e0156321.

Highly conserved gsc1 gene of Pneumocystis jirovecii in patients with or without prior exposure to ehinocandins.

Bonnet, P. L. | Le Gal, S. | Hoffmann, C. V. | Morio, F. | Diabira, F. | de Quélen, A. | Curral, G. | Negri, S. | Cogulet, V. | Huon, J.-F. | Grégoire, M. | Papon, N. | Le Pape, P. | Bouchara, J.-P. | Nevez, G.

https://doi.org/10.1128/AAC.01563-21

PS06

Parasite. 2022, 29.

Selecting a multiplex PCR panel for accurate molecular diagnosis of intestinal protists: a comparative study of Allplex® (Seegene®), G-DiaParaTrio (Diagenode®), and RIDA®GENE (R-Biopharm®) assays and microscopic examination. 

Argy, N. | Nourrisson, C. | Aboubacar, A. | Poirier, P. | Valot, S. | Laude, A. | Desoubeaux, G. | Pomares, C. | Machouart, M. | Le Govic, Y. | Dalle, F. | Botterel, F. | Bourgeois, N. | Cateau, E. | Leterrier, M. | Le Pape, P. | Morio, F. | Houze, S.

https://doi.org/10.1051/parasite/2022003

Brevets

B18.

Multivalent fucose derivatives for use as a drug.

Gouin, S. | Le Pape, P. | Varrot, A.

Demande de brevet européen n° 17 156 368.7 déposée le 15 février 2017.

B17.

Novel fused pyrimidone and triazinone derivatives containing bridged nitrogen, their process of preparation and their therapeutic uses as antifungal and/or antiparasitic agents.

Logé, C. | Guillon, R. | Montoir, D. | Pagniez, F. | Le Pape, P.

PCT WO 2017/021178 A1, 9 février 2017.

B14.

Milieu, dispositif et procédé de test de la sensibilité d'un inoculum de champignons à un agent antifongique.

Le Pape, P. | Pagniez, F.
Université de Nantes FR 2008/0314184.

B10.

Composés en particulier de dérivés urées ou ester de l'acide haloacetamidobenzoïque et leur utilisation pour le traitement de maladies parasitaires.

Le Pape, P. | Fellous, A. | Kalil, J.

Brevet européen n° 03 71 22 86 08,  publié en 2006.

B9.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition.

Le Borgne, M. | Na, Y.M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.

Brevet US 2004067998 A1 publié le 8 avril 2004.

B8.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition.

Le Borgne, M. | Na, Y.M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.

Brevet CN 1473160A publié le 4 février 2004.

B7.

Procédé de détection de la sensibilité des levures aux antifongiques.

Le Pape, P. | Pagniez, F.

Brevet /FR 1 54 056 - A1 2003. 

B6.

New azolyl-substituted indole derivatives and analogs, useful as antifungal and antiparasitic drugs effective e.g. against Candida albicans, Aspergillus fumigatus and Leishmania.

Le Borgne, M. | Na, Y.M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.

Brevet EP 1322638 publié le 2 juillet 2003.

B5.

Indole derivatives and their use as antifungal and/or antiparasitic agents.

Le Borgne, M. | Na, Y.M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.

Brevet CA 2 423 151 A1 publié le 21 mars 2003.

B3.

Activité antimicrotubulaire de nouveaux dérivés benzoylurées: activités antiparasitaires.

Le Pape, P. | Fellouz, A. | Bekesi, C.

Fr. Pat. n° 02.01151, 31 Jan. 2002.

B2.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition.

Le Borgne, M. | Na, Y.M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.


Brevet PCT WO 02/24685 A1 déposé le 21 septembre 2001, publié le 28 mars 2002.

B1.

Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux dérivés de l'indole à titre de principes actifs d'une telle composition

Le Borgne, M. | Na, Y-M. | Pagniez, F. | Le Baut, G. | Le Pape, P. | Abdala, H.

Brevet FR 2 814 073 - A1 déposé le 21 septembre 2000, publié le 22 mars 2002.

Thèse